abstract：:Young and old C57BL/6 male mice were given a diet containing a high dose of vitamin E (VE treatment) and its effect on the immune system was examined before and after the exposure to restraint stress. The VE treatment per se gave rise to a slight increase of splenic T cells in percentage and a significant enhancement ...

journal_title：Experimental gerontology

authors： Wakikawa A,Utsuyama M,Wakabayashi A,Kitagawa M,Hirokawa K

更新日期：1999-11-01 00:00:00

abstract：:Estrogen replacement therapy (ERT) seems to enhance longevity in women. Both gender and aging have been shown to influence the regulation of circadian rhythms, yet little is known about the effect of ERT on circadian regulation. The aim of this study was to determine the effects of ERT (oral conjugated estrogen: Prema...

journal_title：Experimental gerontology

authors： Gudmundsson A,Goodman B,Lent S,Barczi S,Grace A,Boyle L,Ershler WB,Carnes M

更新日期：1999-09-01 00:00:00

abstract：:DNA binding of the ku protein was investigated in peripheral blood mononuclear cells (PBMC) from 24 subjects of different ages (20-89 years old) displaying age-related changes in DNA repair, mitotic responsiveness, and cytokine production. Ku is an heterodimeric protein composed of two subunits of 70 and 80 kDa, which...

journal_title：Experimental gerontology

authors： Frasca D,Barattini P,Tirindelli D,Guidi L,Bartoloni C,Errani A,Costanzo M,Tricerri A,Pierelli L,Doria G

更新日期：1999-08-01 00:00:00

abstract：:Aging is an independent risk factor for the development of atherosclerosis, a vascular abnormality that plays a significant role in the development of many cardiovascular disorders. Animal experiments have demonstrated that aging predisposes the vasculature to advanced atherosclerotic disease and vessel injury and tha...

journal_title：Experimental gerontology

authors： Lundberg MS,Crow MT

更新日期：1999-07-01 00:00:00

abstract：:Fish provide enormous spectrum of longevity and thus present the possibility of multiple mechanisms of senescence. Oxidative stress as a causative agent of senescence and the protective role of antioxidant enzymes were tested in the teleost, Channa punctatus taking peroxidase (POD) (EC 1.1 1.1.7) as the representative...

journal_title：Experimental gerontology

authors： Nayak SB,Jena BS,Patnaik BK

更新日期：1999-06-01 00:00:00

abstract：:A variety of inflammatory proteins has been identified in brains of patients with Alzheimer's disease. The current data suggest that the inflammatory processes are intimately involved in several crucial events in the pathological cascade. Immunohistochemical studies reveal that those parts of the brain wherein the amy...

journal_title：Experimental gerontology

authors： Eikelenboom P,Veerhuis R

更新日期：1999-06-01 00:00:00

abstract：:Reflective of age-associated decline in immune function among elderly individuals is a decrease in in vitro T cell proliferative ability. Impaired T cell proliferation in the elderly may result from disruption of the well-balanced network of regulatory cytokines produced during an immune response. The purpose of this ...

journal_title：Experimental gerontology

authors： Castle SC,Uyemura K,Crawford W,Wong W,Klaustermeyer WB,Makinodan T

更新日期：1999-04-01 00:00:00

abstract：:Aging is associated with changes in lymphocyte subsets and unexplained HLA-DR upregulation on T-lymphocytes. We further investigated this activation, by measuring early (CD69), middle (CD25), and late (HLA-DR) T-lymphocyte activation markers on CD3+ lymphocytes, across subjects (20-100 years) together with serum tumor...

journal_title：Experimental gerontology

authors： Rea IM,McNerlan SE,Alexander HD

更新日期：1999-01-01 00:00:00

abstract：:Prior to three months of age there is little melatonin (MLT) secretion in humans. MLT production then commences, becomes circadian, and reaches its highest nocturnal blood levels between the ages of one to three years. During the remainder of childhood, nocturnal peak levels drop progressively by 80%. In adults, these...

journal_title：Experimental gerontology

authors： Waldhauser F,Kovács J,Reiter E

更新日期：1998-11-01 00:00:00

abstract：:Currently, there is little doubt that the immune system plays a role in the neurodegenerative process in Alzheimer's disease (AD). Inflammatory proteins such as complement components, enzymes, eicosanoids, and cytokines are found in association with cerebral amyloid plaques and may exacerbate the fundamental pathology...

journal_title：Experimental gerontology

authors： Marx F,Blasko I,Pavelka M,Grubeck-Loebenstein B

更新日期：1998-11-01 00:00:00

abstract：:As the analysis of apoptosis is of interest in many basic and clinically oriented investigations, we intend to give a brief overview on the recently most-used methods for detection of apoptotic cells, including the study of morphology, analysis of DNA degradation, DNA end-labeling techniques, flow cytometric analysis,...

journal_title：Experimental gerontology

authors： Sgonc R,Gruber J

更新日期：1998-09-01 00:00:00

abstract：:To understand the mechanism of aging at the cellular level, cellular senescence has been extensively studied as an experimental model of aging in vitro. Although several hypotheses have been proposed for the mechanism of cellular senescence, none of them could give a comprehensive framework to the mechanism. In this s...

journal_title：Experimental gerontology

authors： Kitano H,Imai S

更新日期：1998-08-01 00:00:00

abstract：:Aging is associated with a change in membrane composition that includes a decrease in membrane polyunsaturated fatty acids, including arachidonic acid, and an increase in membrane cholesterol. Alterations in membrane structure are likely to impact on transmitter release, which relies on the fusion of synaptic plasma a...

journal_title：Experimental gerontology

authors： McGahon B,Murray CA,Clements MP,Lynch MA

更新日期：1998-06-01 00:00:00

abstract：:Senescence, a deteriorative process that increases the probability of death of an organism with increasing chronological age, has been found in all metazoans where careful studies have been carried out. There has been much controversy, however, about the potential immortality of hydra, a solitary freshwater member of ...

journal_title：Experimental gerontology

authors： Martínez DE

更新日期：1998-05-01 00:00:00

abstract：:Average life expectancy at birth is a rough measure of the span of healthy, productive life--the functional life span. In the developed countries average life expectancies at birth now range from 76-79 years, six to nine years less than the limit of about 85 years imposed by aging. Aging is the accumulation of changes...

journal_title：Experimental gerontology

authors： Harman D

更新日期：1998-01-01 00:00:00

abstract：:A revolution has occurred in the attitude of biologists toward their intellectual property rights. What today is patentable and highly profitable was, 20 years ago, unpatentable and given away for nothing. The history of this revolution began in the early 1960s when we made the first effort to have self-duplicating ce...

journal_title：Experimental gerontology

authors： Hayflick L

更新日期：1998-01-01 00:00:00

abstract：:We determined the contribution of body fat distribution, peak VO2, fat mass, and dietary intake to variation in plasma lipids in elderly individuals. Volunteers were a healthy cohort of older Caucasian women (n = 75, mean age +/- SD, 72 +/- 5 years) and older men (n = 101, 72 +/- 5 years). We determined fat mass from ...

journal_title：Experimental gerontology

authors： Obisesan TO,Toth MJ,Ades PA,Poehlman ET

更新日期：1997-11-01 00:00:00

abstract：:This article addresses the description of several endocrine-related functions of the brain. It has emerged that steroids and growth factors may influence brain functions, and that brain cells may metabolize sex steroids. The crosstalk between different types of brain cells (neurons, astrocytes, the LHRH (luteinizing h...

journal_title：Experimental gerontology

authors： Martini L,Melcangi RC

更新日期：1997-07-01 00:00:00

abstract：:Diseases of the elderly, including neurodegenerative and cardiovascular disorders and cancer, may develop through the accumulation of "hits" composed of genetic and epigenetic risk factors. The "iceberg" buildup of these hits over time may exceed the tolerance threshold of a particular tissue, thus precipitating disea...

journal_title：Experimental gerontology

authors： Wang E

更新日期：1997-07-01 00:00:00

abstract：:Whereas biological rhythms are now fairly well documented in young healthy adults, reports in elderly are relatively few for obvious reasons, including the difficulty of setting groups matched in age, sociological and professional background, medical history, and not in need of specific medication. Aging may modify on...

journal_title：Experimental gerontology

authors： Touitou Y,Bogdan A,Haus E,Touitou C

更新日期：1997-07-01 00:00:00

abstract：:Previous studies have shown that adult mice increase cold-induced heat production as a result of repeated exposures to cold, but that aged mice do not. The objective of the present study was to investigate changes in heat loss during repeated cold exposures in adult and aged C57BL/6J mice. Mice were partially restrain...

journal_title：Experimental gerontology

authors： Shefer VI,Talan MI

更新日期：1997-05-01 00:00:00

abstract：:Rodent gerontology experiments should be carefully designed and correctly analyzed so as to provide the maximum amount of information for the minimum amount of work. There are five criteria for a "good" experimental design. These are applicable both to in vivo and in vitro experiments: (1) The experiment should be unb...

journal_title：Experimental gerontology

authors： Festing MF

更新日期：1997-01-01 00:00:00

abstract：:The Senescence-Accelerated Mouse (SAM) strains are unique and appropriate models for genetic studies on aging because the SAMP strains have an "accelerated senescence" phenotype for which the SAMR strains are controls, and each SAMP strain has a strain-specific age-associated disorder. Furthermore, because they have g...

journal_title：Experimental gerontology

authors： Higuchi K

更新日期：1997-01-01 00:00:00

abstract：:A crucial assumption of evolutionary theories of aging is that age-specific differences of life history traits may have genetic causes. The present study focuses on the existence of such differences between eight freshly caught populations of Drosophila melanogaster. A highly significant differentiation of the populat...

journal_title：Experimental gerontology

authors： Draye X,Lints FA

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:To assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome. DESIGN:Blood sampling every 20 min for 24 h followed by three daily injections of growth hormon...

journal_title：Experimental gerontology

authors： Rubin CD,Reed B

更新日期：1996-09-01 00:00:00

abstract：:Indigenous DNA adducts (I-compounds) are considered to be a biomarker of aging tissues. Thus far, few studies have been conducted to investigate the accumulation patterns of I-compounds in the brain during aging. Particularly, identities of age-dependent I-compounds have largely remained unknown. In the current study,...

journal_title：Experimental gerontology

authors： Cai Q,Tian L,Wei H

更新日期：1996-05-01 00:00:00

abstract：:The balance between the activities of matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs) is an important control point in tissue remodeling. Previous studies have demonstrated elevated expression of the MMPs collagenase and stromelysin-1 by aged human diploid fibroblasts compared ...

journal_title：Experimental gerontology

authors： Edwards DR,Leco KJ,Beaudry PP,Atadja PW,Veillette C,Riabowol KT

更新日期：1996-01-01 00:00:00

abstract：:We have identified a multistep mechanism by which the DNA virus SV40 overcomes cellular senescence. Expression of SV40 T antigen is required for both transient extension of life span and unlimited life span or immortalization. These effects are mediated through inactivation of function of growth suppressors pRB and p5...

journal_title：Experimental gerontology

authors： Ozer HL,Banga SS,Dasgupta T,Houghton J,Hubbard K,Jha KK,Kim SH,Lenahan M,Pang Z,Pardinas JR,Patsalis PC

更新日期：1996-01-01 00:00:00

abstract：:Several factors involved in regulation of bone mineral metabolism were compared in male and female Fischer 344 rats of different ages (1, 2.5, 6, and 18 months). Plasma 1,25-(OH)2D3 concentrations decreased with age in rats of both genders. Abundance of calbindin-D28K and its mRNA in kidney and calbindin-D9K and its m...

journal_title：Experimental gerontology

authors： Johnson JA,Beckman MJ,Pansini-Porta A,Christakos S,Bruns ME,Beitz DC,Horst RL,Reinhardt TA

更新日期：1995-11-01 00:00:00

abstract：:The aim of this study was to compare the functional and structural changes in similarly identified neurons of the small parietal ganglion in 56 molluscs (Lymnaea stagnalis) of two age groups: adult (10-12 months) and old (20-22 months). No age changes were found in the values of membrane potential, resistance of the n...

journal_title：Experimental gerontology

authors： Frolkis VV,Kvitnitskaya-Ryzhova TYu,Martynenko OA

更新日期：1995-09-01 00:00:00

abstract：:Life table aging rate (LAR) is defined as the age-specific rate of mortality change with age and corresponds to the first derivative or slope of the mortality schedule at each age. We computed the sex-specific LARs for 167 Medfly cohorts, containing a total of approximately 600,000 individuals of each sex. We found th...

journal_title：Experimental gerontology

authors： Carey JR,Liedo P

更新日期：1995-05-01 00:00:00

abstract：:There are three general categories of causes of the cognitive decline associated with aging: disuse, disease, and aging per se. People tend to use certain skills or abilities less with age and, thus, those skills decline due to the disuse. Physical illnesses tend to increase with age, which will tend to compromise cog...

journal_title：Experimental gerontology

authors： Zec RF

更新日期：1995-05-01 00:00:00

abstract：:The correlation between serum levels of pituitary and thyroid hormones and the activity of two antioxidant enzymes (AOE), catalase (CAT) and superoxide dismutase (SOD), in different immune and nonimmune organs of young and old rats was investigated. Serum levels of growth hormone (GH), prolactin (Prl), thyroid-stimula...

journal_title：Experimental gerontology

authors： Bolzán AD,Brown OA,Goya RG,Bianchi MS

更新日期：1995-03-01 00:00:00

abstract：:The objective of this study was to determine whether and to what extent age-related changes occur in atrioventricular (AV) heart valve innervation. The AV valves from three young adult (3 months) and three older (> 24 months) female guinea pigs were studied. An acetylcholinesterase (AChE) localization method was used ...

journal_title：Experimental gerontology

authors： Folan-Curran J,Wang YF,Jew JY,Williams TH

更新日期：1994-09-01 00:00:00

abstract：:Evolutionary aspects of menopause are considered from several perspectives. First, the programmed exhaustion of ovarian oocytes appears to be a general trait of mammals that is not as widely found in other vertebrates. Second, studies on mice suggest that the maternal age effect that accelerates the incidence of Down ...

journal_title：Experimental gerontology

authors： Finch CE

更新日期：1994-05-01 00:00:00

abstract：:Women who seek medical care around the time of menopause frequently report changes in one or more aspects of psychological functioning. The etiology of these symptoms is likely multifactorial and, undoubtedly, individual and sociocultural factors are important determinants. The known psychotropic properties of the sex...

journal_title：Experimental gerontology

authors： Sherwin BB

更新日期：1994-05-01 00:00:00

abstract：:A series of theoretical analyses of mortality were performed on recent data for Mediterranean fruit flies (Ceratitus capitata). Best fit computations were performed using the Marquardt-Levenburg technique on: 1) the classic Gompertz model, 2) the Johnson-Mehl-Avrami (JMA) model from chemical kinetics theory, which is ...

journal_title：Experimental gerontology

authors： Hirsh AG,Williams RJ,Mehl P

更新日期：1994-03-01 00:00:00

abstract：:Primary human dermal fibroblasts isolated from the medial aspect of the proximal forearm of young and old donors were compared for the expression of interstitial collagenase, 72 kDa type IV collagenase, the tissue inhibitor of metalloproteinase type 1, and pro-alpha 2 (I) collagen mRNA at basal levels and after stimul...

journal_title：Experimental gerontology

authors： Burke EM,Horton WE,Pearson JD,Crow MT,Martin GR

更新日期：1994-01-01 00:00:00

abstract：:Aging is associated with a reduction in the maximum density of n-methyl-d-aspartate (NMDA)-sensitive glutamate binding sites in the hippocampus of Fischer 344 rats. This study was designed to investigate the effect of acetyl-l-carnitine (ALCAR) on NMDA receptors in the old rat (24 months) after chronic or single-dose ...

journal_title：Experimental gerontology

authors： Castorina M,Ambrosini AM,Giuliani A,Pacifici L,Ramacci MT,Angelucci L

更新日期：1993-11-01 00:00:00

abstract：:Working from the hypothesis that modest deviations from physiological oxygen tension will influence cell characteristics important for infections/immunity and tumor development, cells were studied at three oxygen tensions during in vitro aging. Primary mouse embryo fibroblasts were established and subsequently passage...

journal_title：Experimental gerontology

authors： Ebbesen P,Hager H,Aboagye-Mathiesen G,Petersen PM,Lützhøft J,Villadsen JA,Zdravkovic M,Dalsgaard AM,Zachar V

更新日期：1993-11-01 00:00:00